Rosetta Stone Protein

Two polypeptides A and B in one organism are likely to interact if their homologs are expressed as a single polypeptide AB in another. The latter polypeptide (AB) is called a Rosetta Stone protein, as it contains information about both A and B. Marcotte et al. [1] have proposed that fusion to form a single polypeptide reduces the entropy of dissociation of A and B. The result is a huge increase in the local concentration of A with respect to B.

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Predicate possible gene function.

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Reference:

Marcotte EM, Pellegrini M, Ng HL, Rice DW, Yeates TO, Eisenberg D: Detecting protein function and protein-protein interactions from genome sequences.

Science 1999, 285:751-753.

Dandekar T, Snel B, Huynen M, Bork P: Conservation of gene order: a fingerprint of proteins that physically interact.Trends Biochem Sci 1998, 23:324-328.

Rosetta Stone proteins: "chance and necessity"? Reiner A Veitia Genome Biology 2002, 3:interactions1001.1-1001.3